Kolloquiumsvortrag, Prof. Partha Roop, Department of Electrical and Computer Engineering, University of Auckland / 03.06.2016

03.06.2016 von 14:15 bis 15:45

Institut für Informatik, Ludewig-Meyn-Straße 2, 24118 Kiel, Raum: Übungsraum 2/K

Titel: The science of bio-remulation for Executable Organ on Chips

Abstact: 

The use of simulation models in biology is extensively studied. Emulation is used, in contrast to simulation, when a controller (such as a pacemaker) for a biological process (the heart) needs validation in real-time. Here, the pacemaker is connected in closed-loop with a living heart. This may occur either during the clinical trial phase with human subjects or animal models. We argue that such emulation is expensive, time limiting, and has associated ethical considerations. We propose the science of remulation (reverse-emulation) as an alternative paradigm. Here, we develop executable models of the biological process (say the cardiac conduction system) that is realisable on a reprogrammable computer chip.

Such an ``Executable Organ on Chip'' (ExOoC) provides high-fidelity and real-time capabilities like a real heart, from the point of view of the pacemaker. Remulation of such ``Executable Organ on Chip'' (ExOoC) has not only excellent potential for medical device validation and certification but also can be used for personalisation and
non-invasive diagnostics. We have developed the first high-fidelity remulation model of the cardiac conduction system and have used this to validate a pacemaker in real-time.

Prof. Dr. Reinhard von Hanxleden

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