Near infrared fluorescent materials and sensors for biomedical applications

03.06.2019 um 16:00 bis 03.07.2019 um 17:00

In our research we investigate and create functional (nano)materials for biomedical applications. We are especially interested in 1D and 2D materials that provide novel photophysical properties such as near Infrared (nIR) fluorescence. The nIR range (800-1700 nm) of the spectrum is beneficial for optical applications because it falls into the tissue transparency window. One example of such a material are semiconducting single-walled carbon nanotubes (SWCNTs). SWCNTs fluoresce in the nIR and their optoelectronic properties are very sensitive to changes in the chemical environment and they are therefore versatile building blocks for biosensors. In my talk I will cover the following current research topics of my group:

1)    I will show fundamental insights into SWCNT photophysics and how capabilities of SWCNT-based fluorescent sensors can be enhanced. SWCNTs were for example conjugated to nanobodies that can be targeted in vivo to any Green Fluorescent Protein (GFP) moiety. These SWCNTs were used for single-particle tracking and microrheology measurements in living drosophila embryos.

2)    The corona phase around SWCNTs was tailored to enhance selectivity and photophysics of SWCNT-based sensors for the important neurotransmitters dopamine and serotonine. These sensors can be used to image neurotransmitter efflux from neuronal cells and blood cells.

3)    We introduce a novel class of 2D nIR fluorescent silicate nanosheets, characterize their photophysical properties as a function of their dimensionality and use them for in vivo particle tracking as well as standoff detection in living plants.

4)    Immune cells were used for programmed transport and release of nanoscale cargo. The cells take up SWCNT-based sensors, transport them and release them again.

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